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. Author manuscript; available in PMC: 2016 May 25.
Published in final edited form as: Biochim Biophys Acta. 2010 Sep 16;1812(3):353–363. doi: 10.1016/j.bbadis.2010.09.004

Fig. 5.

Fig. 5

Human Tau expression in Tg(eno2:MAPT) zebrafish neurons. A: A western blot was made with protein lysate from wild-type zebrafish brain (lane 1), control post-mortem human cortex (lane 2) and Tg(eno2:MAPT) brain (lane 3). The blot was probed using an antibody to human Tau (upper panel) followed by an antibody to β-actin (lower panel). Abundant expression of human 4R-Tau is seen in transgenic zebrafish compared with the six isoforms in normal human brain [111]. B: Sections of Tg(eno2:MAPT) zebrafish brain were labeled using the antibody to human Tau used in the western blot experiment shown in panel A and a histochemical reaction yielding a red product. The micrograph shows a brainstem neuron with dense Tau immunoreactivity in the cell body and proximal axon, resembling neurofibrillary tangles shown in Fig. 1B [111].