Table 7.
Tissue Distributions of Fentanyl, Norfentanyl, Acetyl Fentanyl and Acetyl Norfentanyl (concentrations shown in units of mg/L or mg/Kg).
Case | Drug | PB | HB | Vitreous | Brain | Liver | Bile | Urine |
---|---|---|---|---|---|---|---|---|
1 | Fentanyl | 0.021 | 0.032 | 0.029 | 0.108 | 0.210 | 0.320 | 1.200 |
Norfentanyl | 0.003 | 0.004 | 0.005 | 0.003 | 0.028 | 0.250 | 0.840 | |
Acetyl Fentanyl | 0.009 | 0.026 | 0.031 | 0.080 | 0.180 | 0.140 | 0.980 | |
Acetyl Norfentanyl | 0.002 | 0.002 | 0.002 | 0.005 | 0.011 | 0.340 | 0.470 | |
2 | Fentanyl | 0.015 | 0.014 | 0.018 | 0.047 | 0.052 | 0.061 | 0.011 |
Norfentanyl | 0.003 | 0.002 | 0.002 | 0.001 | 0.007 | 0.032 | 0.056 | |
Acetyl Fentanyl | 0.012 | 0.006 | 0.001 | 0.037 | 0.029 | 0.023 | 0.003 | |
Acetyl Norfentanyl | 0.001 | 0.001 | 0.001 | 0.006 | 0.005 | 0.023 | 0.017 | |
3 | Fentanyl | 0.019 | 0.016 | 0.012 | 0.077 | 0.084 | 0.025 | 0.015 |
Norfentanyl | 0.008 | 0.003 | 0.004 | 0.004 | 0.002 | 0.010 | 0.026 | |
Acetyl Fentanyl | 0.006 | 0.002 | 0.004 | 0.021 | 0.036 | 0.022 | 0.015 | |
Acetyl Norfentanyl | 0.001 | 0.001 | 0.001 | 0.004 | 0.004 | 0.013 | 0.032 | |
4 | Fentanyl | 0.005 | 0.019 | 0.008 | – | 0.040 | 0.081 | 0.034 |
Norfentanyl | 0.001 | 0.001 | 0.001 | – | 0.004 | 0.003 | 0.012 | |
5 | Fentanyl | 0.005 | 0.020 | 0.029 | 0.140 | 0.062 | 0.062 | 0.042 |
Norfentanyl | 0.0002 | 0.001 | 0.001 | 0.0003 | 0.003 | 0.003 | 0.006 | |
6 | Fentanyl | 0.027 | 0.038 | 0.032 | 0.110 | 0.340 | 0.150 | 0.064 |
Norfentanyl | 0.003 | 0.005 | 0.002 | 0.001 | 0.014 | 0.019 | 0.038 | |
8 | Fentanyl | 0.015 | 0.041 | 0.008 | 0.120 | 0.098 | 0.046 | 0.051 |
Norfentanyl | 0.002 | 0.005 | 0.001 | 0.002 | 0.012 | 0.029 | 0.120 | |
11 | Acetyl Fentanyl | 0.310 | 0.700 | 0.290 | 1.100 | 0.690 | 0.540 | 6.200 |
Acetyl Norfentanyl | 0.063 | 0.086 | 0.025 | 0.064 | 0.190 | 0.300 | 3.400 | |
12 | Acetyl Fentanyl | 0.400 | 0.400 | 0.100 | 1.700 | 1.800 | 0.100 | – |
Acetyl Norfentanyl | 0.003 | 0.004 | 0.001 | 0.005 | 0.020 | 0.015 | – | |
13 | Acetyl Fentanyl | 0.560 | 0.980 | 0.300 | 1.100 | 1.200 | 0.800 | 0.130 |
Acetyl Norfentanyl | 0.002 | 0.004 | 0.002 | 0.007 | 0.016 | 0.095 | 0.100 | |
14 | Acetyl Fentanyl | 0.600 | 0.670 | 0.900 | 1.400 | 1.900 | 4.800 | 16.000 |
Acetyl Norfentanyl | 0.036 | 0.034 | 0.019 | 0.044 | 0.160 | 1.400 | 18.000 |
PB, peripheral blood; HB, heart blood; – indicates specimen was not available for analysis; tissue distribution studies were not conducted on Cases 7, 9 and 10.