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. 2016 May 25;7:179. doi: 10.3389/fphys.2016.00179

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Copyright © 2016 Matchkov and Krivoi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Short-term hindlimb suspension specifically and transiently alters the α2 Na,K-ATPase protein content (A), mRNA content (B), and electrogenic activity (C) in rat soleus muscle. (A,B) Relative α1 (white bars) and α2 (gray bars) Na,K-ATPase protein and mRNA contents in the homogenates from muscles of control rats and after 6–72 h of hindlimb suspension (data normalized to the average level of expression under control conditions). (C) The electrogenic transport activity of the α2 Na,K-ATPase isozyme measured in the extrajunctional and junctional membrane regions of muscle fibers. ^**p < 0.01 compared to corresponding control. Modified from Kravtsova et al. (2015a, 2016).