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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: J Cardiovasc Electrophysiol. 2015 Oct 13;27(1):110–119. doi: 10.1111/jce.12833

Figure 3. Optical mapping mutant Cx43.

Figure 3

(A) Example isochronal maps of patterned NRVMs at baseline and 15 min MS. Pixels with active signal inside the dashed rectangles were used for CV analysis (horizontal rectangles for transverse CV and vertical rectangles with red arrows for longitudinal CV). The only Ad368A monolayer with conduction at 15 min MS is shown (black outline shows full mapping field). (B) Both longitudinal and transverse CV significantly slowed after 15 and 30 min MS in all groups (p<0.05 for each, within-group comparison to baseline, n=5 each). Ad368A monolayers behaved significantly differently than all other groups during MS († p<0.01 longitudinal, * p<0.05 transverse, n=5). (C) Ad368A monolayers had significantly reduced CV at 5min MS (p<0.01 relative to baseline). CV returned to normal after removal of MS.