Table 4. Frequency of secondary variables analysed on the 28th day of life.
| Secondary variables | Control group n (%) | Butantan group n (%) | p value |
|---|---|---|---|
| Use of oxygen at 28 days | 72 (45.28) | 77 (57.04) | 0.05 |
| Radiography consistent with BPD | 52 (65.00) | 57 (72.15) | 0.33 |
| Intracranial hemorrhage (total) | 39 (24.53) | 43 (31.16) | 0.20 |
| Grade I | 17 (43.59) | 17 (39.53) | 0.94 |
| Grade II | 5 (12.82) | 7 (16.28) | |
| Grade III | 10 (25.64) | 10 (23.26) | |
| Grade IV | 7 (17.95) | 9 (20.93) | |
| PDA (n=297) | 50 (31.45) | 62 (44.93) | 0.02 |
| Early sepsis (n=297) | 58 (36.48) | 50 (36.23) | 0.97 |
| Late sepsis (n=293) | 59 (37.58) | 51 (37.50) | 0.99 |
| Pulmonary hemorrhage (n=297) | 20 (12.58) | 16 (11.59) | 0.80 |
| Pneumothorax (n=297) | 13 (8.18) | 12 (8.70) | 0.87 |
| Interstitial emphysema (n=292) | 12 (7.64) | 23(17.04) | 0.01 |
| Necrotizing enterocolitis (n=297) | 11 (6.92) | 11 (7.97) | 0.83 |
| Mechanical ventilation time (days) | 8 | 12 | 0.06 |
| Total oxygen therapy time (days) | 17 | 22 | 0.35 |
Continuous variables were analyzed using the Student’s t or Mann-Whitney test, as appropriate. Qualitative variables were analyzed using the χ2 or Fischer’s exact test, as appropriate. BPD: bronchopulmonary displasia; PDA: persistent ductus arteriosus.