Table 1.
Characteristics of the cell lines used in the study.
Cell line | Gender, age, disease, MSI status | Characterized deletions, mutations, and comments |
---|---|---|
CCD841CoN | Female, 21-week gestation (fetus), normal colon | According to ATCC, the definitive evidence of epithelial origin is lacking |
HT29 | Female, 44 years, colorectal adenocarcinoma, MSS | Deletion in APC (del1555_2843) |
Mutation in p53 (codon 273: R273H) | ||
Mutation in BRAF (codon 600: V600E) | ||
Mutation in PI3KCA (P449T) | ||
HCT116 | Male, 48 years, colorectal carcinoma (proximal), HNPCC, MSI | Mutation in Ras (codon 13: G13D) |
Mutation in PI3KCA (codon 1047: H1047R) | ||
Deletion in β-catenin (del45) |