Table 1. Open questions in the cannabinoid receptor-1 (CB 1) receptor field.
| Open questions in the endocannabinoid field. |
|---|
| Is the cell type-specific CB
1 receptor signaling an open door to
develop new therapeutic tools? |
| Is the endocannabinoid system exclusively a retrograde
neuromodulator system? |
| How is the subcellular CB
1 receptor distributed in the different
cell types? |
| How can CB 1 receptors control neurotransmitter co-release? |
| Which physiological and pathological functions are modulated
by intracellular CB 1 receptors? |
| Is there specific or differential CB
2 receptor expression in
different cell types? |
| Is the allosteric modulation of CB
1 receptors a good therapeutic
approach for pathological conditions? |
| Will it be possible to create compounds that target CB
1 receptors
in specific cell types or subcellular localizations? |
CB 1, cannabinoid receptor-1; CB 2, cannabinoid receptor-2.