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. 2016 May 24;5:F1000 Faculty Rev-986. [Version 1] doi: 10.12688/f1000research.7998.1

Table 4. Biomarkers of AKI and outcomes in kidney transplantation.

Urine biomarkers OUTCOMES
Short-term (1 week) Long-term (>1 year follow-up)
Delayed graft function Graft failure at 1 year Graft failure + death
Recipient IL-18
  Hall 2012 58
  Hall 2010 55 		OR 5.1 (1.14, 2.28)*
HR 1.26 (0.74, 2.14)
Recipient NGAL
  Nauta 2011 59
  Parikh 2006 56
  Hall 2010 55
  Hall 2012 58

OR 6.8 (1.42, 32.2)*		 HR 1.61 (1.04, 2.50)
HR 1.5 (1.2, 1.8)
HR 1.2 (1.0, 1.5) †
Recipient NAG
  Nauta 2011 59 		HR 1.4 (1.2, 1.7)
Recipient KIM-1
  Nauta 2011 59 		HR 1.3 (1.1, 1.7)
Recipient H-FABP
  Nauta 2011 59 		HR 1.5 (1.2, 1.8)

All values in ( ) are 95% confidence intervals, unless otherwise noted.

*greater than cut-off versus less than cut-off, † per 100 ng/mg increase.

AKI, acute kidney injury; H-FABP, heart fatty acid binding protein; HR, hazard ratio (continuous unless otherwise noted); IL-18, interleukin-18; KIM-1, kidney injury molecule-1; NAG, N-acetyl-beta-D-glucosaminidase; NGAL, neutrophil gelatinase-associated lipocalin; OR, odds ratio.