Table 1.
Recent drugs in use or development (MOA: mechanism of action; TRAP: therapeutic reclamation of apoptotic proficiency).
| Name | MOA | Status | Source (Reference, trial number) |
|---|---|---|---|
| Tenofovir disoproxil fumarate (TDF) | RT inhibition | Approved 2012, Truvada | [32] |
| Emtricitabine, FTC | RT inhibition | ||
| Tenofovir alafenamide (TAF, GS-7340) | RT inhibition | Investigational prodrug of TFV | [33] |
| Rilpivirine (TMC-278) | NNRT inhibition | Recruiting | [34] |
| Cabotegravir (GSK 744) (S/GSK1265744) | InST inhibition | Not yet recruiting | [35, 36] |
| Maraviroc | CCR5 antagonism | Ongoing trial | NCT01505114 [37] |
| Ciclopirox | TRAP | Recruiting | [38, 39] |
| Deferiprone |