Table 1.
Clinical profile, DBS stimulation parameters, and outcome in patients with adult-onset axial dystonia.
| Patient 1 | Patient 2 | Patient 3 | Patient 4 | |
|---|---|---|---|---|
| Age at the time of surgery/gender | 66/F | 53/M | 59/F | 67/M |
| Age of onset | 64 | 50 | 56 | 52 |
| Anatomic involved | Lower face and jaw, neck, arms, trunk, leg | Neck, trunk | Trunk | Eyes, trunk, neck |
| Pharmacotherapy prior to DBS | Trihexyphenidyl, baclofen, cyclobenzaprine, botulinum toxin type A | Levodopa-carbidopa, trihexyphenidyl, baclofen, tetrabenazine, botulinum toxin type A | Trihexyphenidyl, levodopa-carbidopa | Baclofen, botulinum toxin type A |
| Pre-operative BFM score/percent improvement after DBS | 36/87.5% | 16/90.62% | 4/100% | 43.5/72.4% |
| Pre-operative TWSTRS severity scale/percent improvement after DBS | 28/71.43% | 19/84.21% | N/A (no cervical dystonia) | 17/58.82% |
| Stimulus parameters for best outcome (volts, micro-seconds, Hertz) | Left: 3.5, 150, 60 Right: 3.8, 150, 60 |
Left: 3.4, 90, 130 Right: 3.6, 120, 130 |
Left: 4.0, 210, 60 Right: 4.0, 210, 60 |
Left: 4.5, 210, 80 Right: 4.0, 120, 80 |
| Stimulation contact | Right 2 −ve, case +ve Left: 2 −ve, case +ve |
Right 1 −ve, case +ve Left: 2 −ve, case +ve |
Right 0 −ve, case +ve Left: 1 −ve, case +ve |
Right 0 −ve, Case +ve Left: 1 −ve, case +ve |