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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Expert Rev Clin Immunol. 2015 Sep 1;11(12):1379–1390. doi: 10.1586/1744666X.2015.1083861

Figure 2.

Figure 2

(A) Microscopic appearance of the myocardium of a GTKO pig heart transplanted heterotopically into an immunosuppressed baboon almost 6 months previously, showing advanced features of thrombotic microangiopathy, with numerous vessels occluded by thrombus with surrounding areas of ischemic fibrosis. Reproduced from The Lancet, Vol .379, Ekser et al, Clinical xenotransplantation: the next medical revolution?, pp672-83, Copyright 2012, with permission from Elsevier [3].

(B) Microscopic appearance of the myocardium of a GTKO/CD46/TBM pig heart transplanted heterotopically into an immunosuppressed baboon one year previously. No significant histopathological changes are seen. (Courtesy Muhammad Mohiuddin MD, NHLBI, NIH, Bethesda, MD, USA.)