TABLE 4-2.
| Major Symptom Domain/Subcategory | % of Subjects With First Symptomc |
|---|---|
| Cognitive | 40 |
| Memory loss | 45 |
| Aphasia/dysphasia | 13 |
| Frontal/executive | 13 |
| Confusion/disorientation | 11 |
| Visuospatial | 9 |
| Cognitive, unspecified | 5 |
| Decreased alertness | 2 |
| Apraxia | 2 |
|
| |
| Cerebellar | 22 |
|
| |
| Gait | 84 |
| Limb ataxia | 12 |
| Unspecified | 4 |
|
| |
| Constitutional | 21 |
| Dizziness/vertigo | 41 |
| Fatigue/lethargy | 21 |
| Sleep disturbance | 10 |
| Headache | 7 |
| Urinary incontinence | 7 |
| Weight loss | 7 |
| Gastrointestinal upset | 3 |
| Palpitations | 3 |
|
| |
| Behavioral | 20 |
| Agitation/irritability | 36 |
| Depression | 16 |
| Anger/aggression | 8 |
| Apathy | 8 |
| Personality change | 8 |
| Aberrant motor | 4 |
| Mania | 4 |
| Unspecified | 4 |
| Bizarre behavior | 4 |
| Social isolation | 4 |
| Panic attack | 4 |
|
| |
| Motor | 10 |
| Extrapyramidal | 25 |
| Pyramidal | 17 |
| Handwriting change | 17 |
| Cramps | 8 |
| Unspecified | 8 |
| Myoclonus, action | 8 |
| Tremor, unspecified | 8 |
| Fasciculations | 8 |
|
| |
| Sensory | 9 |
| Paresthesia | 60 |
| Pain | 20 |
| Special senses | 10 |
| Sensory, unspecified | 10 |
|
| |
| Visual | 7 |
| Unspecified | 67 |
| Diplopia | 33 |
a
Data from Rabinovici GD, et al, Neurology.20 www.neurology.org/content/66/2/286.short.
b
First symptoms based on 146 first symptoms among 114 subjects with sporadic Jakob-Creutzfeldt disease; as some subjects had more than a single first symptom, the total percentages of major categories total is more than 100%.
c
Percentages for subcategory refer to percent of patients within the major category symptom and may not total 100% because of rounding.