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. Author manuscript; available in PMC: 2016 May 25.
Published in final edited form as: Contrast Media Mol Imaging. 2010 Nov 30;6(4):219–228. doi: 10.1002/cmmi.421

Figure 6.

Figure 6

The dependence of the CEST effect of Yb-DO3A-oAA on concentration for the amide (solid circles) and amine (open circles). (A) The CEST effects of the amine and the amide of Yb-DO3A-oAA each increased with increasing concentration, but the ratio of the CEST effects was insensitive to changes in concentration. (B) The Hanes calibration [eqn (4)] was used to measure the r1sat relaxivities and chemical exchange rates of the agent, and the linearities of each calibration confirmed that the chemical exchange of the amide and amine are sufficiently described by a two-pool model.