Table 1.
Hypoxia-regulated miRNAs
| Study | miRNAs upregulated by hypoxia | miRNAs downregulated by hypoxia |
|---|---|---|
| Hua (2006), nasopharyngeal carcinoma cells, DFOM treatment, 20 h | miR-15, miR-188, miR-210, miR-30d, miR-155, miR-181b | Let-7-e, Let-7-g, miR-16, miR-26b, miR-30b, Let-7-f, Let-7-a, Let-7-c, Let-7-d, miR-15b, miR-20a, miR-20b, miR-224 |
| Kulshreshtha (2007), colon and breast cancer cells, 0.2% O2, 8–48 h | miR-103, miR-106a, miR-107, miR-125b, miR-181a, miR-181c, miR-192, miR-21, miR-210, miR-213, miR-23a, miR-23b, miR-24-1, miR-26a, miR-27a, miR-93, miR-181b, miR-195, miR-26b, miR-30b | |
| Hebert (2007), head and neck squamous carcinoma cells, 1% O2, 1 h or 5% O2, 8 h | Let-7-i, miR-148a, miR-148b, miR-15a, miR-191, miR-200a, miR-210, miR-214, miR-373, miR-429, miR-498, miR-563, miR-572, miR-628, miR-637, miR-7, miR-98, Let-7-e, Let-7-g, miR-30b | miR-195, miR-29b, miR-30e-5p, miR-374, miR-422b, miR-101, miR-122a, miR-141, miR-186, miR-197, miR-19a, miR-320, miR-424, miR-565 |
| Donker (2007), primary human cytotrophoblasts, 1% O2, 48 h | miR-125a, miR-152, miR-188, miR-191, miR-193b, miR-200b, miR-206, miR-210, miR-213, miR-23a, miR-23b, miR-27b, miR-30a-5p, miR-30c, miR-30d, miR-339, miR-452, miR-491, miR-512-5p, miR-93 | miR-150, miR-155, miR-181b, miR-373, miR-128b, miR-181d, miR-196a, miR-196b, miR-200a, miR-25, miR-424, miR-449, miR-519e, miR-92, miR-489 |
| Guimbellot (2009), colon cells, liquid–liquid interface. | let-7b, let-7e, miR-125a, miR-128a, miR-137, miR-148a, miR-185, miR-199a, miR-20, miR-204, miR-210, miR-213, miR-214, miR-23b, miR-26a, miR-299, miR-30a-3p, miR-30c, miR-335, miR-342, miR-150, miR-155, miR-16, miR-181b, miR-26b, miR-30b | miR-216, miR-9 |
| Voellenkle (2012), HUVEC, 1% O2, | miR-210 | |
| Choudhry (2014), breast cancer cells, 1% O2, 24 h | let-7b, let-7e, miR-103, miR-107, miR-151, miR-191, miR-193b, miR-210, miR-24-1, miR-27a, miR-27b, miR-30d, miR-339, miR-98, miR-181d | miR-125a, miR-15a, miR-200b, miR-342, miR-141 |
| Camps (2014), breast cancer cells, 1% O2, 16, 32 and 48 h | miR-1, miR-106b-3p, miR-1246, miR-1269a, miR-140-3p, miR-141-5p, miR-143-3p, miR-151a-3p, miR-181c-3p, miR-192-5p, miR-194-5p, miR-195-3p, miR-203a, miR-215-5p, miR-27a-5p, miR-28-3p, miR-3065-3p, miR-30d-5p, miR-30d-3p, miR-30e-3p, miR-3140-3p, miR-3158-3p, miR-338-5p, miR-33b-5p, miR-203b-3p, miR-3619-3p, miR-3677-3p, miR-378c, miR-378d, miR-378i, miR-3913-5p, miR-3928-3p, miR-4504, miR-4746-5p, miR-4760-5p, miR-548a-3p, miR-627-5p, miR-92b-3p, miR-942-5p, miR-99b-5p, miR-24-2-5p, miR-27a-3p, miR-30b-3p, miR-30b-5p | miR-145-3p, miR-222-5p, miR-4521, miR-29b-1-5p, hsa-let-7f-1-3p, miR-1260a, miR-1260b, miR-1275, miR-15b-3p, miR-19a-3p, miR-19b-3p, miR-19b-1-5p, miR-22-3p, miR-221-5p, miR-23a-5p, miR-23b-5p, miR-296-3p, miR-32-3p, miR-33a-3p, miR-3613-5p, miR-424-3p, miR-4466, miR-455-3p, miR-505-5p, miR-573, miR-92a-1-5p, miR-93-3p, miR-940 |