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. Author manuscript; available in PMC: 2016 May 25.
Published in final edited form as: Int J Cancer. 2014 Nov 11;136(10):2341–2351. doi: 10.1002/ijc.29301

Figure 3.

Figure 3

Inhibition of the noncanonical pathway reduces DNA damage repair. (a) Effect of doxorubicin treatment on Rel-B nuclear localization. Nuclear and cytoplasmic fractions were extracted from OCI-LY3, RCK8 and Daudi cells at indicated time points after treatment with doxorubicin, followed by immunoblotting for Rel-B, Actin and histone 3. (b) Measurement of γ-H2AX (+) and OTM of OCI-LY3, RCK8 and Daudi cells expressing p100- or Luc-shRNA after doxorubicin treatment. Error bars represent the standard deviation obtained from three independent experiments. In (b) cells were harvested at different time points following 1 h treatment with doxorubicin (2 μg/mL). * p < 0.01.