Table 2.

Associations Between Measures of Adiposity and Thyroid Hormone Parameters at Age 7

	n	TSH (mU/L)			FT3 (pmol/L)			FT4 (pmol/L)			FT3 to FT4 Ratiob
		β-(std)	95% CI	P Valuea	β-(std)	95% CI	P Valuea	β-(std)	95% CI	P Valuea	β-(std)	95% CI	P Valuea
BMI (age 7)
Model 1	3014	0.03	0.004, 0.06	.05	0.13	0.10, 0.16	5.30 × 10−16	−0.05	−0.08, −0.02	.001	0.15	0.12, 0.18	1.45 × 10−20
Model 2	3014	0.02	−0.01, 0.06	.13	0.16	0.13, 0.19	6.62 × 10−21	−0.10	−0.13, −0.06	1.64 × 10−08	—	—	—
Model 3	3014	0.03	−0.004, 0.07	.09	0.12	0.08, 0.16	4.02 × 10−10	−0.08	−0.12, −0.04	.00003	0.12	0.09, 0.16	5.71 × 10−11
Weight (age 7)
Model 1	3014	0.02	−0.01, 0.05	0.15	.11	0.08, 0.14	8.16 × 10−17	−0.04	−0.07, 0.02	.001	0.13	0.10, 0.15	8.46 × 10−22
Model 2	3014	0.01	−0.01, 0.04	0.35	.13	0.11, 0.16	5.20 × 10−22	−0.08	−0.11, −0.05	6.30 × 10−09	—	—	—
Model 3	3014	0.02	−0.001, 0.05	0.08	.09	0.06, 0.13	5.62 × 10−10	−0.05	− 0.08 − 0.03	.0001	0.08	0.06, 0.11	2.07 × 10−07
Height (age 9)
Model 1	3014	−0.002	−0.03, 0.03	0.92	.07	0.04, 0.10	8.07 × 10−06	−0.03	−0.06, 0.002	.03	0.09	0.06, 0.12	2.91 × 10−08
Model 2	3014	−0.01	−0.04, 0.02	0.68	.09	0.05, 0.12	1.20 × 10−07	−0.06	−0.09, −0.03	.0003	—	—	—
Model3c	3014	0.002	−0.03, 0.03	0.99	.08	0.05, 0.12	1.29 × 10−06	−0.06	−0.10, −0.02	.001	0.09	0.06, 0.12	1.47 × 10−07
Fat mass (age 9)
Model 1	3014	0.01	−0.02, 0.04	0.74	.18	0.15, 0.21	4.32 × 10−25	−0.04	−0.08, −0.01	.02	0.18	0.15, 0.21	1.86 × 10−25
Model 2	3014	−0.003	−0.03, 0.03	0.87	.21	0.17, 0.24	1.17 × 10−30	−0.10	−0.13, −0.06	2.67 × 10−08	—	—	—
Model 3d	2538	−0.008	−0.04, 0.03	0.64	.12	0.09, 0.16	4.02 × 10−12	−0.07	−0.10, −0.03	.002	0.11	0.08, 0.14	8.06 × 10−11
FMI (age 9)
Model 1	3014	0.01	−0.03, 0.04	0.75	.17	0.13, 0.20	1.56 × 10−22	−0.04	−0.07, 0.002	.04	0.17	0.14, 0.20	1.54 × 10−22
Model 2	3014	−0.003	−0.04, 0.03	0.84	.19	0.16, 0.23	2.16 × 10−27	−0.10	−0.13, −0.06	2.42 × 10−07	—	—	—
Model 3d	2538	−0.01	−0.04, 0.02	0.65	.13	0.09, 017	3.99 × 10−12	−0.07	−0.11, −0.03	.002	0.12	0.08, 0.15	7.98 × 10−11
Lean mass (age 9)
Model 1	3014	0.01	−0.02, 0.06	0.18	.10	0.06, 0.13	6.64 × 10−09	−0.05	−0.09, −0.02	.002	0.12	0.09, 0.16	1.73 × 10−13
Model 2	3014	0.02	−0.02, 0.05	0.35	.12	0.09, 0.15	3.46 × 10−12	−0.09	−0.12, −0.05	8.91 × 10−07	—	—	—
Model 3d	2538	0.02	−0.01, 0.04	0.11	.01	−0.02, 0.03	.56	−0.03	−0.05, −0.01	.01	0.02	−0.0001, 0.04	.05

Model 1 adjusted for age and sex model 2 adjusted for model 1 and other thyroid hormone parameters. Model 3 adjusted for model 2 and height, markers of social class, and early life environment (home ownership, maternal age at birth of child, maternal highest educational qualification, maternal smoking in pregnancy, family adversity index, and parents and home score). P, strength of evidence against the null hypothesis of no association.

^aCalculated using the Wald test.

^bNot adjusted for other thyroid hormone parameters.

^cNot adjusted for height.

^dA total of 476 individuals with missing data.