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. 2015 Dec 23;101(2):523–532. doi: 10.1210/jc.2015-3566

Figure 4.

Figure 4.

The number of nonhormone-expressing endocrine cells (CPHN cells) in OND and OT2D. A and B, The number of nonhormone-expressing endocrine cells (CPHN cells) per islet cross-section is increased in the OT2D subjects (0.11 ± 0.03 vs 0.03 ± 0.01 cells/islet, OT2D vs OND, *, P < .01). C and D, The number of nonhormone-expressing endocrine cells (CPHN cells) present in scattered clusters of endocrine cells is increased in OT2D (1.54 ± 0.21 vs 0.30 ± 0.05 cells/mm2, OT2D vs OND, ***, P < .0001). E and F, The number of endocrine cells (both hormone expressing and nonhormone expressing) present in scattered clusters of endocrine cells is increased in OT2D (13.53 ± 1.31 vs 9.41 ± 1.67 cells/mm2 of pancreas, OT2D vs OND, ^, P < .05). Panels A, C, and E, black circles, OND subjects; black squares, OT2D subjects. Panels B, D, and F, white bars, OND subjects; black bars, OT2D subjects.