FIG. 7.

Effect of TCPOBOP on liver weight and bile flow in male and female mice. Corn oil vehicle or TCPOBOP (3 mg/kg) was administered daily (IP) for 4 consecutive days to male and female mice (n = 5–6 per treatment group). On day 5, mice were anesthetized and bile was collected for 40 min. Liver weight is expressed as a percent of bodyweight (BW) (upper panel). Bile flow rates were normalized to BW (middle panel) and liver weight (lower panel). Data represent means ± SEM. Asterisks (*) denote statistically different from vehicle control (P < 0.05). Females (F), males (M), 1,4-bis(2-[3,5-dichloropyridyloxy])benzene (TCPO). Color image is available in the online version of the article.