Table 3.
Risk of Incident Diabetes in Women and Men by Muscle Variables and Overweight Status
| Normal Weight HR (95% CI) | P Value | Overweight/Obese HR (95% CI) | P Value | P for Interaction | ||
|---|---|---|---|---|---|---|
| Women | BMI 18–24.9 kg/m2 | BMI ≥ 25 kg/m2 | ||||
| Abdominal muscle area | ||||||
| Unadjusted | 0.47 (0.25–0.89) | .02 | 1.49 (1.26–1.76) | <.001 | .001 | |
| +Model 1a | 0.38 (0.18–0.81) | .01 | 1.28 (1.03–1.58) | .03 | .003 | |
| +Model 2b | 0.37 (0.17–0.82) | .02 | 1.26 (1.01–1.58) | .04 | .004 | |
| +Model 3c | 0.37 (0.17–0.83) | .02 | 1.23 (0.98–1.54) | .08 | .004 | |
| Thigh muscle area | ||||||
| Unadjusted | 0.70 (0.40–1.23) | .22 | 1.57 (1.32–1.88) | <.001 | .007 | |
| +Model 1a | 0.79 (0.40–1.56) | .49 | 1.44 (1.15–1.81) | .002 | .009 | |
| +Model 2b | 0.73 (0.35–1.52) | .40 | 1.41 (1.11–1.79) | .005 | .01 | |
| +Model 3c | 0.58 (0.27–1.27) | .18 | 1.28 (1.00–1.64) | .05 | .01 | |
| Total lean mass | ||||||
| Unadjusted | 0.76 (0.41–1.43) | .40 | 1.42 (1.20–1.70) | <.001 | .06 | |
| +Model 1a | 0.71 (0.38–1.34) | .29 | 1.32 (1.09–1.60) | .004 | .08 | |
| +Model 2b | 0.73 (0.37–1.44) | .37 | 1.21 (1.00–1.48) | .055 | .12 | |
| +Model 3c | 0.66 (0.32–1.34) | .24 | 1.10 (0.89–1.36) | .40 | .18 | |
| Men | BMI 18–24.9 kg/m2 | BMI ≥ 25 kg/m2 | ||||
| Abdominal muscle area | ||||||
| Unadjusted | 1.10 (0.65–1.86) | .71 | 1.14 (0.93–1.39) | .21 | .94 | |
| +Model 1a | 0.94 (0.52–1.71) | .84 | 0.94 (0.74–1.19) | .58 | .50 | |
| +Model 2b | 1.14 (0.61–2.13) | .69 | 0.95 (0.73–1.23) | .69 | .44 | |
| +Model 3c | 1.13 (0.60–2.12) | .71 | 0.94 (0.73–1.22) | .64 | .42 | |
| Thigh muscle area | ||||||
| Unadjusted | 0.68 (0.40–1.16) | .16 | 0.97 (0.80–1.18) | .79 | .21 | |
| +Model 1a | 0.64 (0.28–1.44) | .28 | 0.84 (0.63–1.11) | .22 | .27 | |
| +Model 2b | 0.70 (0.29–1.73) | .44 | 0.82 (0.60–1.11) | .20 | .28 | |
| +Model 3c | 0.81 (0.32–2.08) | .66 | 0.87 (0.63–1.18) | .36 | .31 | |
| Total lean mass | ||||||
| Unadjusted | 1.12 (0.62–2.03) | .71 | 1.02 (0.84–1.23) | .88 | .73 | |
| +Model 1a | 1.11 (0.62–2.00) | .73 | 0.95 (0.77–1.17) | .62 | .66 | |
| +Model 2b | 1.23 (0.65–2.30) | .53 | 0.93 (0.75–1.16) | .53 | .65 | |
| +Model 3c | 1.19 (0.63–2.26) | 0.59 | 0.87 (0.69–1.09) | .22 | .54 | |
Abbreviation: CI, confidence interval.
Model 1 included age, race, and clinical site (+ total abdominal area for abdominal muscle area analyses + total thigh area for thigh muscle area analyses).
Model 2 included model 1 + physical activity, smoking, lipids, and hypertension.
Model 3 included model 2 + visceral fat area.