Table 3.
Changes in BMI, Body Fat Percentage, and Parameters of Glucose and Lipid Metabolism After Leptin Replacement in Lipodystrophy Patients
| Before leptin | After leptin | P Value | |
|---|---|---|---|
| BMI, kg/m2 | 24.49 ± 4.12 | 23.62 ± 4.35 | <.001 |
| Body fat: total percentage fat | 18.85 ± 9.06 | 14.44 ± 9.90 | .05 |
| apoCIII, mg/dLa | 23.4 (14.5, 40.1) | 21.37 (16.7, 28.3) | .34 |
| TGs, mg/dLa | 483.47 (252.8, 745.8) | 253.07 (154.5, 357) | <.001 |
| Non-HDL cholesterol, mg/dL | 185.9 ± 84.35 | 145.2 ± 66.05 | <.001 |
| LDL, mg/dL | 98.97 ± 43.76 | 89.33 ± 37.18 | .03 |
| HDL, mg/dL | 30.52 ± 9.02 | 31.83 ± 9.04 | .42 |
| NASH-CRN fat score | 1.75 ± 0.97 | 0.67 ± 0.58 | <.001 |
| HbA1c | 8.38 ± 2.06 | 6.91 ± 1.5 | <.001 |
| Fasting glucose, mg/dL | 178 ± 78.5 | 128.7 ± 48.49 | <.001 |
| Fasting insulin, μU/mLb | 44.48 ± 40.74 | 36.64 ± 32.47 | .24 |
| Fasting C-peptide, ng/mL | 3.68 ± 2.08 | 3.55 ± 1.95 | .92 |
| QUICKI | 0.27 ± 0.03 | 0.29 ± 0.04 | .01 |
| OGTT glucose AUC | 51 078 ± 14 720 | 44 113 ± 14 823 | .008 |
| OGTT insulin AUC | 21 986 ± 33 490 | 25 981 ± 56 566 | .62 |
Data are expressed as mean ± SD. Statistically significant results are marked in bold.
a
Expressed in geometric mean (25th and 75th percentiles).
b
Fasting insulin levels in both insulin users and nonusers.