Table 3. Summary of additional VWF SNPs analysis and association in 115 HSE cases and 158 EIMS controls.
Scandinavian | All individuals | |||||||
---|---|---|---|---|---|---|---|---|
SNP marker | Position | Minor Allele | MAF cases | MAF controls | OR (95% CI) | P-value | OR (95% CI) | P-value |
rs12369177 | 5943781 | T | 0.404 | 0.366 | 0.97 (0.65–1.43) | 0.86 | 1.18 (0.81–1.70) | 0.39 |
rs11063961 | 5944277 | G | 0.191 | 0.187 | 1.00 (0.69–1.45) | 0.98 | 1.02 (0.71–1.47) | 0.90 |
rs12300917 | 5949319 | A | 0.149 | 0.190 | 0.80 (0.54–1.21) | 0.29 | 0.75 (0.51–1.11) | 0.15 |
rs7301070 | 5950551 | G | 0.423 | 0.314 | 1.46 (0.98–2.16) | 0.06 | 1.61 (1.11–2.33) | 0.01 |
rs2238110 | 5950838 | G | 0.423 | 0.314 | 1.46 (0.98–2.16) | 0.06 | 1.61 (1.11–2.33) | 0.01 |
rs917857 | 5952085 | A | 0.415 | 0.478 | 0.75 (0.55–1.00) | 0.05 | 0.77 (0.58–1.03) | 0.08 |
rs917858 | 5952199 | C | 0.423 | 0.316 | 1.43 (0.97–2.13) | 0.07 | 1.59 (1.09–2.30) | 0.01 |
rs917859 | 5952374 | A | 0.423 | 0.329 | 1.50 (1.11–2.02) | 0.008 | 1.50 (1.12–2.00) | 0.006 |
rs2239138 | 5952819 | A | 0.427 | 0.314 | 1.46 (0.98–2.16) | 0.06 | 1.63 (1.13–2.37) | 0.009 |
rs12829271 | 5953060 | A | 0.427 | 0.314 | 1.46 (0.98–2.16) | 0.06 | 1.63 (1.13–2.37) | 0.009 |
rs4764521 | 5954584 | A | 0.254 | 0.213 | 1.27 (0.91–1.79) | 0.16 | 1.26 (0.91–1.76) | 0.16 |
MAF = minor allele frequency; HWE = Hardy-Weinberg Equilibrium; OR = odds ratio; CI = confidence interval. (Chr12 SNPs positions (in bp) (Genome build 36.3). Table summarizing the analysis of the new 6 and 3 associated SNPs (the analysis was run in a total of 36 SNPs, data not shown).
Scandinavian columns: represent analysis of OR and P-value made in Scandinavian 115 HSE cases and 428 EIMS controls;
All individuals columns: represent analysis of OR and P-value made in Scandinavian and non-Scandinavian 119 HSE cases and 508 EIMS controls.