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. 2016 May 25;11(5):e0154827. doi: 10.1371/journal.pone.0154827

Fig 5. Behavioral phenotype comparison between R222S and WT mice.

Fig 5

Sensitivity to a mechanical stimulus (determined by measuring the 50% threshold in the von Frey test) in 8–9-week-old mice (A) and 36–38-week-old mice (B); to a thermal stimulus (determined by measuring paw withdrawal latency in the Hargreaves test) in 8–9-week-old mice (C) and 36–38-week-old mice (D); to a cold stimulus (determined by measuring the number of nociceptive behaviors in the cold plate test) in 8–9-week-old mice (E) and 36–38-week-old mice (F). Open and closed columns show WT (8–9 weeks old, n = 10; 36–38 weeks old, n = 6) and R222S mice (8–9 weeks old, n = 12; 36–38 weeks old, n = 5), respectively. Data are presented as mean and S.E.M. (*p < 0.05; two-sided Student’s t test).