Table 1.

Selected pharmacologic treatments for conditions in which central sensitization has been demonstrated

Condition	Pharmacologic treatments	References
Fibromyalgia	Duloxetine* , milnacipran* , pregabalin* , amitryptiline, paroxetine, citalopram	[8]
Irritable bowel syndrome	Imipramine, amitryptiline, gabapentin, pregabalin	[21,54]
Chronic fatigue syndrome	Amitryptiline, doxepin, citalopram, escitalopram	[53]
Chronic headache	Amitryptyline, nortriptyline, divalproex, propranolol, gabapentin, topirimate	[22]
Complex regional pain syndrome	Amytal, ketamine	[44]

^*Food and Drug Administration approved.