Fig. 2.

A) BDNF protein levels are reduced in the brain of CaMK-BDNF^KO mice. Levels of BDNF protein in 12 week old mice were measured in wild-type mice (n=5, black bars), BDNF^neo;BDNF^lox mice (n=3, gray bars) and CaMK-BDNF^KO mice (n=5, white bars). ViC = visual cortex, Hp = hippocampus, T/Hy = thalamus/hypothalamus, M/Hi = mid/hindbrain, DRGs = dorsal root ganglia. B) Body weights of wild type, BDNF heterozygotes (Het), CaMKcre; BDNF^lox/+ (CKCBlox) mice and CaMK-BDNF^KO mice. Histograms show the body weights of animals aged 12–48 weeks, with the weights binned in 5 gram amounts. (On the abscissa 25 = 20.0–24.9g, 30 = 25.0–29.5g etc.)