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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Neurobiol Dis. 2015 Apr 26;79:51–58. doi: 10.1016/j.nbd.2015.04.006

Fig. 1.

Fig. 1

A: Schematic drawing of a horizontal slice containing PC and EC. B: Field potential recordings obtained from PC and EC areas during application of 4AP and VU0240551 (10 μM). Note that blocking KCC2 with VU0240551 virtually abolishes ictal discharges in both brain regions whereas interictal discharges continue to occur. Enlarged portion of the recordings is shown in insets with traces that are further expanded at the start of an ictal discharge during 4AP and during interictal activity after application of VU0240551. C: Plots showing the average number of ictal and interictal discharges in PC and EC. Vertical lines in both graphs indicate the application of VU0240551. Note that 30 min application of VU0240551 blocked the occurrence of ictal discharges in both PC and EC while it increased the average number of interictal events in both regions.