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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Neurobiol Dis. 2015 Apr 26;79:51–58. doi: 10.1016/j.nbd.2015.04.006

Fig. 3.

Fig. 3

A and B: Bar graphs showing the average interval of occurrence (A) and duration (B) of interictal discharges recorded from PC and EC under control conditions (i.e., 4AP) and during application of 10 μM VU0240551, 10 μM bumetanide and 50 μM bumetanide. Note that blocking KCC2 decreases the interval of occurrence and the duration of interictal discharges in both regions whereas blocking NKCC1 with bumetanide (10 μM) does not have a significant effect on interval of occurrence and duration of interictal discharges. C: Bar graphs showing the proportion of interictal events, in PC and EC, co-occurring with ripples and fast ripples under control conditions (i.e., 4AP), and during application of 10 μM VU0240551, 10 μM bumetanide and 50 μM bumetanide. Note that application of VU0240551 or bumetanide (50 μM) induces a significant increase in the proportion of interictal spikes co-occurring with ripples in the PC. *p < 0.05 and **p < 0.0001.