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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Neurobiol Dis. 2015 Apr 26;79:51–58. doi: 10.1016/j.nbd.2015.04.006

Fig. 4.

Fig. 4

A: Effects induced by 100 μM CLP257 on the epileptiform discharges recorded from the PC and EC during bath application of 4AP. B: Plot showing the average number of ictal discharges in PC and EC before and after the application of CLP257. Vertical line indicates the application of the drug. C: Bar graphs showing the duration of ictal discharges recorded from PC and EC under control conditions (i.e., 4AP) and during application of 100 μM CLP257. Note that enhancing KCC2 activity increases the duration of ictal discharges in both region without affecting their rate of occurrence. D and E: Bar graphs showing the average interval of occurrence (D) and duration (E) of interictal discharges recorded from PC and EC under control conditions and during application of CLP257. Note that CLP257 only decreases the duration of interictal discharges only in PC. *p < 0.05 and **p < 0.01.