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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Pflugers Arch. 2015 Jan 22;467(11):2325–2335. doi: 10.1007/s00424-015-1686-4

Fig. 2.

Fig. 2

Changes induced by interfering with KCC2 and/or NKCC1 activities on the two types of interictal discharge induced by 4AP in the CA3 subfield. The effects induced by VU0240551 (10 μM) (a) as well as by 10 μM (b) and 50 μM (c) bumetanide are shown on continuous recordings obtained under control conditions and after application of each of these drugs. In each panel, the inserts below represent averages of short- and long-lasting interictal events. d Graphs showing change in interval of occurrence of both short- and long-lasting events after application of each drug. Note that blocking KCC2 activity with either VU0240551 or 50 μM bumetanide influences both short- and long-lasting events, whereas blocking NKCC1 with low doses of bumetanide (10 μM) does not cause any appreciable change