Table 1.
Baseline characteristics of the CRIC Study sample
| Rapid progressors (cases) | Stable CKD (controls) | p-value | |
|---|---|---|---|
| Clinical characteristics | |||
| Age (years) | 60.1 ± 10.2 | 57.8 ± 11.3 | 0.04 |
| Male sex (%) | 57 | 64 | |
| Race/ethnicity | white 31% | white 51% | |
| black 55% | black 35% | <0.001 | |
| other 14% | other 14% | ||
| Hypertension (%) | 95 | 87 | 0.004 |
| Systolic blood pressure (mmHg) | 134.5 ± 21.4 | 121.9 ± 20.0 | <0.001 |
| Diastolic blood pressure (mmHg) | 72.1 ± 13.8 | 70.1 ± 12.7 | 0.14 |
| Body mass index (kg/m2) | 32.5 ± 7.8 | 32.1 ± 7.1 | 0.53 |
| Diabetes (%) | 55 | 44 | 0.03 |
| Cardiovascular disease (%) | 47 | 36 | 0.04 |
| Smokers (%) | 20 | 12 | 0.03 |
| Laboratory measures | |||
| Serum creatinine (mg/dL) | 1.86 ± 0.6 | 1.82 ± 0.6 | 0.58 |
| Baseline eGFR (mL/min/1.73 m2)† | 41.7 ± 13.3 | 45.0 ± 14.5 | 0.02 |
| Follow-up eGFR (mL/min/1.73 m2) | 24.7 ± 10.5 | 45.0 ± 11.2 | <0.001 |
| 24h urine protein (g) | 0.9 ± 1.6 | 0.8 ± 1.3 | 0.27 |
| Hemoglobin (mg/dL) | 12.7 ± 1.7 | 13.3 ± 1.9 | 0.002 |
| Bicarbonate (mmol/L) | 24.3 ± 3.4 | 24.7 ± 2.9 | 0.12 |
| Phosphate (mg/dL) | 3.7 ± 0.7 | 3.6 ± 0.6 | 0.05 |
| FGF-23 (RU/mL) | 205.7 ± 249.1 | 159.4 ± 137.0 | 0.02 |
| Insulin (μIU/mL) | 25.7 ± 25.6 | 26.8 ± 33.4 | 0.73 |
| Total cholesterol (mg/dL) | 177.2 ± 44.3 | 176.1 ± 38.4 | 0.78 |
| HDL cholesterol (mg/dL) | 47.7 ± 13.0 | 48.6 ± 15.7 | 0.55 |
| LDL cholesterol (mg/dL) | 95.2 ± 34.4 | 94.7 ± 29.8 | 0.89 |
| Triglycerides (mg/dL) | 158.2 ± 112.7 | 154.0 ± 96.6 | 0.66 |
†
baseline eGFR using the CKD-EPI equation was 43.9 ± 13.9 for cases and 44.6 ± 13.4 mL/min/1.73 m2 for controls
Conversion factor for units: serum creatinine in mg/dL to mmol/L, x88.4