Table 3.

Renal arteriovenous gradients for metabolites nominally associated with rapid CKD progression in CRIC

Metabolite	# of individuals with V/A <1	# of individuals with V/A ≥1	Mean V/A Ratio	p-value
homogentisate*	22	0	0.37	<0.001
4-hydroxymandelate*	22	0	0.37	<0.001
3-methyladipate-pimelate	23	0	0.60	<0.001
cytosine	21	2	0.80	<0.001
glucuronate	23	0	0.85	<0.001
uric acid	20	3	0.98	0.02
phenylalanine	10	13	1.00	0.9
threonine	3	20	1.07	<0.001
methionine	2	21	1.10	<0.001
arginine	0	23	1.16	<0.001
creatinine	23	0	0.81	<0.001

Abbreviation: V/A = venous to arterial ratio

^*no data on these metabolites for one study participant