Table 5.
Meta-analysis of American Indian and SAMAFS data
| Marker | American Indians | SAMAFS | Combined | ||||
|---|---|---|---|---|---|---|---|
| Alleles (1/2) | Effecta | P-value | Effect | P-value | Effect | P-value | |
| TC | |||||||
| rs6511727 | (C/A) | −2.4% | 0.006193 | −0.8% | 0.255555 | −1.4% | 0.0120 |
| rs4804576b | (A/C) | −4.0% | 1.660 x 10−7 | −1.7% | 0.016029 | −2.7% | 1.242 x 10−7 |
| rs2278426 | (T/C) | −3.5% | 5.045 x 10−6 | −2.0% | 0.005842 | −2.7% | 2.563 x 10−7 |
| rs2116876 | (A/G) | −3.8% | 1.114 x 10−6 | −1.7% | 0.010212 | −2.5% | 3.684 x 10−7 |
| rs7248924 | (G/A) | −2.6% | 5.884 x 10−4 | −1.8% | 0.006122 | −2.2% | 1.514 x 10−5 |
| rs322122 | (A/G) | −2.5% | 0.000924 | −1.8% | 0.008235 | −2.1% | 3.049 x 10−5 |
| HDL-C | |||||||
| rs2278426 | (T/C) | −3.2% | 0.000741 | −4.5% | 0.00002 | −3.8% | 8.526 x 10−8 |
a
Effect is expressed as a multiplier (in %) per copy of the “1” allele;
b
Results for SAMAFS are given for rs737337, which is 100% concordant with rs4804576