Skip to main content
. Author manuscript; available in PMC: 2017 Apr 22.
Published in final edited form as: Curr Opin Genet Dev. 2016 Apr 22;36:34–40. doi: 10.1016/j.gde.2016.03.008

Figure 2. Oncogene activation through global rearrangements of TADs.

Figure 2

Two TADs that are located several megabases away are represented as triangles (as in Figure 1). The first TAD possesses an enhancer and an expressed gene. The second TAD does not express the proto-oncogene. Global rearrangements that occur at breakpoints (dashed black line) fuse the two far away TADs by inverting the sequence in between the two TADs and create two chimeric TADs. The gene in the first TAD is no longer expressed and the oncogene in the second TAD is now expressed by activation of the relocated enhancer. Enhancer is represented by a red dot and genes by green rectangles.