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A theoretical model summarizing the effects of alcohol abuse and cessation on rate of nicotine metabolism via the C-oxidation pathway as measured by the nicotine metabolite ratio (NMR). Alcohol abuse may induce the rate of nicotine metabolism via the CYP2A6 pathway. Our study finds that among alcohol abusers, abstinence from alcohol for 4 to 7 weeks results in a significant decrease in rate of nicotine metabolism suggesting a normalization of this effect.
