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. Author manuscript; available in PMC: 2017 Feb 6.
Published in final edited form as: Curr Opin Genet Dev. 2016 Feb 6;36:1–7. doi: 10.1016/j.gde.2016.01.002

Figure 1. Contribution of chromatin architecture to our understanding of cancer.

Figure 1

Chromatin architecture has been implicated in the pathogenesis of cancer through multiple lines of evidence. The normal topology of the genome has been shown to predispose certain cell types to the acquisition of certain chromosomal translocations such as the MYC/IgH translocations associated with certain types of lymphoma (left panel). The genetic mutation of components involved in chromatin looping, including the cohesin complex (red/green/blue ring) and CTCF (orange squares), has also been observed in many cancer types (center panel). These mutations (illustrated by *) likely cause quantitative changes in factor binding, illustrated here by a change in ChIP-seq signal. Lastly, disruption of regulatory regions that serve as the anchors for looping machinery has been identified in cancer and multiple other diseases (right panel).