Table 1.

Nanoparticle size range used for intra-articular injection to treat OA.

Material description	Size	Refs.
Chitosan, berberine chloride (BBR)	50 - 400 nm	(Zhou et al., 2015)
Hyaluronic acid, bovine serum albumin, brucine	150 nm	(Chen et al., 2013)
Neutral core, cationic surface (e.g. ethyl cellulose, Eudagrit RL100)	100 - 150 nm	(Morgen et al., 2013)
Tristearin, hydrogenated soya phosphatidylcholine, Aceclofenac, chondroitin sulfate (CS)	140 - 160nm	(Bishnoi, Jain, Hurkat, & Jain, 2014)
Chitosan, Kartogenin	150 nm and 1800 nm	(Kang, Ko, Kim, & Im, 2014)
Chitosan chloride, hyaluronic acid, salmon-calcitonin	160 - 230 nm	(Ryan et al., 2013)
Tetraethylene glycol methacrylate, cyclohexyl methacrylate	270 nm	(Whitmire et al., 2012)
PLGA, brucine	250 – 260 nm and 1250 nm	(Chen et al., 2014)
Soya lechitin, diacerein, Chondoritin sulfate	390 - 400 nm	(Jain et al., 2014)
Pyridine - Poly(2-hydroxyethyl methacrylate), IL-1Ra/model protein	300, 500, and 900 nm (tunable)	(Singh et al., 2014) (Agarwal et al., 2015)