Table 4.
List of human proteins targeted by salicylates.
| Protein name | Salicylate | Reference |
|---|---|---|
| Arachidonate 5-lipoxygenase (ALOX5) | 5-aminosalicylic acid, sulfasalazine | (70) |
| Tumor necrosis factor alpha (TNFα) | Sulfasalazine | (67) |
| Cyclooxygenase-1 (COX-1) | Aspirin | (63, 71) |
| Cyclooxygenase-2 (COX-2) | Aspirin, sodium salicylate | (63, 71, 72) |
| Nuclear factor-kappaB (NF-κB) | Aspirin, sodium salicylate | (69) |
| Cathepsin A (CTSA) | Aspirin | (73) |
| Inhibitor of nuclear factor-kappa-B kinase subunit beta (Iκκ-β) | Aspirin, sodium salicylate | (68) |
| Ribosomal S6 kinase 2 (RSK2) | Aspirin, salicylic acid | (74) |
| Adenosine monophosphate-activated protein kinase (AMPK) | Sodium salicylate | (75) |
| Peroxisome proliferator-activated receptor gamma (PPARγ) | Amorfrutins | (17) |
| Ferrochelatase (FECH) | Salicylic acid | (76) |
| Acetyltransferase p300 (P300) | Salsalate, salicylate | (77) |
| Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) | Salicylic acid, amorfrutins B1 and FN2, acetyl 3-aminoethyl salicylic acid, 5-aminosalicylic acid | (14) |
| High mobility group box 1 (HMGB1) | Salicylic acid, amorfrutin B1, acetyl 3-aminoethyl salicylic acid | (15) |
| Cyclin-dependent kinase 2 (CDK2) | Aspirin, salicylic acid | (78) |