FIGURE 7.

Summary of MeCP2, MBD1, MBD2, and MBD3 spatiotemporal expression patterns. MBD2 is expressed throughout the body with lower relative expression in the brain compared to other MBD proteins at postnatal day 7 (P7) and postnatal day 42 (P42). MBD2 is also up regulated temporally in the adult spleen and small intestine. In contrast, MeCP2 is most highly expressed in the brain. MBD1 and MBD3 are highly expressed in the brain at early ages, but down regulated in the adult brain. Adapted from Wood et al. (2016).