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Concentration of IL-2 and activation of tumour-infiltrating lymphocytes. Low concentrations of IL-2 may promote the regulatory microenvironment and tumour growth. High concentrations of IL-2 activate immune system cells, such as CD8+, CD4+, and γδ T cells and NK cells; these cells produce proinflammatory cytokines, such as IFN-γ, and eliminate tumour cells.
