Figure 4.
The glucose‐lowering effect of ALA/SFC, which is not a secondary effect due to reduced food intake, depends on the amount of ALA/SFC administered per day. ZDF rats were orally administered 150/23.6 or 300/47.1 mg·kg−1 ALA/SFC once a day or 150/23.6 mg·kg−1 ALA/SFC twice a day (b.i.d.) for 6 weeks. In addition, the pair‐feeding group (group 8) was given the same amount of food once daily as that given to rats administered 300/47.1 mg·kg−1 ALA/SFC in the previous week (group 7). (A) Plasma glucose levels. (B) HbA1c levels. **P < 0.01, ***P < 0.001 vs the vehicle‐administered group. # P < 0.05 vs the pair‐feeding group. $ P < 0.05, $$ P < 0.01, $$$ P < 0.001 vs the 150/23.6 mg·kg−1 ALA/SFC group (Tukey's test, n = 8).