Table 4. Toxicity in cycle #1 and cycle #2—DPD mutation positive cohort after dose reduction.

Toxicity (n=17)	Cycle 1 [%]	Cycle 2 [%]	P value
HFS	9 [53]	7 [41]	0.5
Mucositis	12 [71]	4 [24]	0.016
Diarrhoea	15 [88]	6 [36]	0.006
Myelosuppression	3 [18]	5 [29]	0.27

DPD, dihydropyrimidine dehydrogenase; HFS, hand-foot syndrome.