Table 3.
Top five upstream regulators and target molecules.
| Upstream regulator | Log ratio | Molecule type | Predicted state | p-Value | Target molecules in dataset |
|---|---|---|---|---|---|
| TLR3 | 0.847 | Transmembrane receptor | Activated | 7.92E-08 | ARG2, ATF3, CMPK2,CXCL11, CXCL3, FAS, IFI44L, IFI6, IFIT1, IFIT2, IFIT3, IRF7, ISG15, ISG20, MX1, RIPK1, TICAM1, TLR3 |
| MAVS | 0.724 | Other | Activated | 2.54E-05 | CMPK2, IFIT1, IFIT2, IFIT3, IRF7, ISG15, ISG20 |
| IRF7 | 1.005 | Transcription regulator | Activated | 4.24E-07 | CMPK2, IFI44L, IFI6, IFIT1, IFIT2, IFIT3, IFITM1, IRF7, ISG15, ISG20, MX1, SAMD9L, TAP1, XAF1 |
| TICAM1 | 0.594 | Other | Activated | 1.60E-05 | CMPK2, CXCL11, CXCL3, FAS, IFIT1, IFIT2, IFIT3, IRF7, ISG15, ISG20, TLR3 |
| PPARD | 1.165 | Ligand-dependent nuclear receptor | Activated | 1.87E-03 | ACTA2, C10orf35, IFI44L, MMP9, PDE4C, PDPK1, PPARD, TCEA3, VLDLR |