Table 2. The associations of FSTL1 polymorphisms with the risk of RCC and ccRCC.
| Genotype | RCC cases No (%) | ccRCC cases No (%) | Controls No (%) | Adjusted OR (95% CI)a | P-valuea | Adjusted OR (95% CI)b | P-valueb |
|---|---|---|---|---|---|---|---|
| rs11708686 (RCC n = 412, ccRCC n = 364, Control n = 836) H-W P = 0.415 | |||||||
| GG | 70 (16.99) | 64 (17.58) | 154 (18.42) | 1.000 (Reference) | – | – | – |
| AG | 203 (49.27) | 178 (48.90) | 423 (50.60) | 1.069 (0.769–1.486) | 0.691 | 1.027 (0.730–1.445) | 0.877 |
| AA | 139 (33.74) | 122 (33.52) | 259 (30.98) | 1.181 (0.830–1.682) | 0.355 | 1.136 (0.788–1.638) | 0.494 |
| AG+AA | 342 (83.01) | 300 (82.42) | 682 (81.58) | 1.115 (0.816–1.524) | 0.493 | 1.067 (0.773–1.474) | 0.692 |
| G allele | 343 (41.63) | 306 (42.00) | 731 (43.72) | 1.000 (Reference) | – | – | – |
| A allele | 481 (58.37) | 422 (58.00) | 941 (56.28) | 1.095 (0.925–1.298) | 0.291 | 1.077 (0.903–1.286) | 0.408 |
| rs1105219 (RCC n = 397, ccRCC n = 352, Control n = 829) H-W P = 0.262 | |||||||
| AA | 87 (21.91) | 77 (21.88) | 168 (20.27) | 1.000 (Reference) | – | – | – |
| AG | 205 (51.64) | 183 (51.99) | 428 (51.63) | 0.933 (0.685–1.270) | 0.658 | 0.935 (0.679–1.289) | 0.682 |
| GG | 105 (26.45) | 92 (26.14) | 233 (28.11) | 0.860 (0.607–1.218) | 0.395 | 0.854 (0.594–1.229) | 0.395 |
| AG+GG | 310 (78.09) | 275 (78.13) | 661 (79.73) | 0.906 (0.676–1.214) | 0.508 | 0.906 (0.669–1.229) | 0.527 |
| A allele | 379 (47.73) | 337 (47.87) | 764 (46.08) | 1.000 (Reference) | – | – | – |
| G allele | 415 (52.27) | 367 (52.13) | 894 (53.92) | 0.930 (0.785–1.103) | 0.405 | 0.927 (0.777–1.106) | 0.400 |
| rs2673704 (RCC n = 412, ccRCC n = 362, Control n = 851) H-W P = 0.170 | |||||||
| TT | 21 (5.10) | 18 (4.97) | 34 (4.00) | 1.000 (Reference) | – | – | – |
| CT | 135 (32. 77) | 124 (34.25) | 241 (28.32) | 0.915 (0.509–1.644) | 0.765 | 0.982 (0.531–1.815) | 0.953 |
| CC | 256 (62.14) | 220 (60.77) | 576 (67.69) | 0.705 (0.400–1.243) | 0.228 | 0.710 (0.392–1.288) | 0.260 |
| CT + CC | 391 (94.90) | 344 (95.03) | 817 (96.00) | 0.770 (0.440–1.347) | 0.360 | 0.795 (0.442–1.429) | 0.443 |
| T allele | 177 (21.48) | 160 (22.10) | 309 (18.16) | 1.000 (Reference) | – | – | – |
| C allele | 647 (78.52) | 564 (77.90) | 1393 (81.84) | 0.810 (0.658–0.997) | 0.046 | 0.783 (0.632–0.971) | 0.026 |
| rs1259293 (RCC n = 417, ccRCC n = 368, Control n = 855) H-W P = 0.124 | |||||||
| TT | 247 (59.23) | 212 (57.61) | 515 (60.23) | 1.000 (Reference) | – | – | – |
| CT | 140 (33.57) | 130 (35.33) | 307 (35.91) | 0.946 (0.736–1.217) | 0.666 | 1.023 (0.788–1.327) | 0.864 |
| CC | 30 (7.19) | 26 (7.07) | 33 (3.86) | 2.004 (1.190–3.375) | 0.009 | 2.014 (1.171–3.463) | 0.011 |
| CT + CC | 170 (40.77) | 156 (42.39) | 340 (39.77) | 1.042 (0.820–1.323) | 0.737 | 1.112 (0.868–1.426) | 0.400 |
| T allele | 634 (76.02) | 554 (75.27) | 1337 (78.19) | 1.000 (Reference) | – | – | – |
| C allele | 200 (23.98) | 182 (24.73) | 373 (21.81) | 1.134 (0.932–1.380) | 0.209 | 1.179 (0.962–1.445) | 0.112 |
| rs1402372 (RCC n = 386, ccRCC n = 344, Control n = 835) H-W P = 0.744 | |||||||
| CC | 58 (15.03) | 52 (15.12) | 114 (13.65) | 1.000 (Reference) | – | – | – |
| AC | 172 (44.56) | 157 (45.64) | 395 (47.31) | 0.868 (0.603–1.251) | 0.449 | 0.889 (0.609–1.298) | 0.543 |
| AA | 156 (40.41) | 135 (39.24) | 326 (39.04) | 0.963 (0.664–1.397) | 0.844 | 0.928 (0.630–1.366) | 0.704 |
| AC+AA | 328 (84.97) | 292 (84.88) | 721 (86.35) | 0.909 (0.645–1.282) | 0.586 | 0.901 (0.631–1.287) | 0.567 |
| C allele | 288 (37.31) | 261 (37.94) | 623 (37.31) | 1.000 (Reference) | – | – | – |
| A allele | 484 (62.69) | 427 (62.06) | 1047 (62.69) | 1.004 (0.842–1.199) | 0.961 | 0.979 (0.815–1.176) | 0.820 |
| rs1259339 (RCC n = 386, ccRCC n = 340, Control n = 789) H-W P = 0.610 | |||||||
| CC | 21 (5.44) | 18 (5.29) | 34 (4.31) | 1.000 (Reference) | – | – | – |
| CT | 131 (33.94) | 109 (32.06) | 271 (34.35) | 0.788 (0.440–1.412) | 0.423 | 0.762 (0.412–1.407) | 0.385 |
| TT | 234 (60.62) | 213 (62.65) | 484 (61.34) | 0.794 (0.450–1.403) | 0.427 | 0.842 (0.464–1.529) | 0.573 |
| CT + TT | 365 (94.56) | 322 (94.71) | 755 (95.69) | 0.792 (0.452–1.386) | 0.413 | 0.813 (0.452–1.463) | 0.489 |
| C allele | 173 (22.41) | 145 (21.32) | 339 (21.48) | 1.000 (Reference) | – | – | – |
| A allele | 599 (77.59) | 535 (78.68) | 1239 (78.52) | 0.950 (0.771–1.170) | 0.627 | 1.010 (0.810–1.258) | 0.932 |
aRCC patients vs healthy controls.
bccRCC patients vs healthy controls.
Abbreviations: FSTL1 = follistatin-like 1; RCC = renal cell carcinoma; ccRCC = clear cell renal cell carcinoma; CI = confidence interval.
OR = odds ratio; H-W = Hardy-Weinberg.