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. 2016 May 26;6:26830. doi: 10.1038/srep26830

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Copyright © 2016, Macmillan Publishers Limited

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(a) Ghrh, (b) Srif, (c) Pomc and (d) AgRP mRNA levels were significantly downregulated 24 hrs after a bolus ICV injection of chemerin (100 nmol; n = 4) compared to vehicle injection (n = 4) whereas (e) Npy mRNA expression was unaffected. (f–j) Chronic infusion of chemerin (100 nmol/day/14 days, n = 7) had no effect on (f) Ghrh, (g) Srif, (i) AgRP and (j) Npy mRNA levels compared to vehicle infusion (n = 7), but (h) Pomc mRNA expression was significantly upregulated. Data shown are mean ± SEM and presented relative to SD; *p < 0.05, **p < 0.01. Chem, chemerin.