Table 1. Pathway analysis of genes found by microarray showing the strongest difference after injection of RA.
Pathway | Annot.genes | Sig. genes | pvalue* |
---|---|---|---|
inflammatory response | 152 | 50 | 1.36 × 10−17 |
immune response | 197 | 50 | 7.14 × 10−14 |
positive regulation of I-κB kinase/NF-κB cascade | 130 | 33 | 1.03 × 10−9 |
antigen processing and presentation | 54 | 21 | 2.41 × 10−9 |
antigen processing and presentation of exogenous peptide antigen via MHC class II | 17 | 13 | 6.76 × 10−9 |
chemotaxis | 53 | 20 | 8.65 × 10−9 |
innate immune response | 62 | 20 | 7.33 × 10−8 |
ruffle | 58 | 19 | 1.26 × 10−7 |
immunoglobulin mediated immune response | 15 | 11 | 1.34 × 10−7 |
Ras protein signal transduction | 60 | 19 | 1.95 × 10−7 |
chemokine activity | 39 | 15 | 4.97 × 10−7 |
neutrophil chemotaxis | 28 | 13 | 5.27 × 10−7 |
The most significant changes were in genes related to inflammatory and immune responses. The 12 pathways with the highest percentage of changes are shown. *p value calculated by Fisher test.