Table 1. Pathway analysis of genes found by microarray showing the strongest difference after injection of RA.

Pathway	Annot.genes	Sig. genes	pvalue*
inflammatory response	152	50	1.36 × 10−17
immune response	197	50	7.14 × 10−14
positive regulation of I-κB kinase/NF-κB cascade	130	33	1.03 × 10−9
antigen processing and presentation	54	21	2.41 × 10−9
antigen processing and presentation of exogenous peptide antigen via MHC class II	17	13	6.76 × 10−9
chemotaxis	53	20	8.65 × 10−9
innate immune response	62	20	7.33 × 10−8
ruffle	58	19	1.26 × 10−7
immunoglobulin mediated immune response	15	11	1.34 × 10−7
Ras protein signal transduction	60	19	1.95 × 10−7
chemokine activity	39	15	4.97 × 10−7
neutrophil chemotaxis	28	13	5.27 × 10−7

The most significant changes were in genes related to inflammatory and immune responses. The 12 pathways with the highest percentage of changes are shown. *p value calculated by Fisher test.