Figure 1. Phylogenetic tree illustrating the evolutionary relationship of CYP144A1 to other mycobacterial CYP144 family P450s.
Protein sequence alignment of CYP144A1 was made with CYP144 sequences from other mycobacteria. Protein sequence conservation between the CYP144 proteins in all species ranges from 58–100%, with higher conservation of CYP144A1 sequence identity within the Mtb complex (MTBC), and the lowest conservation in the M. avium complex (MAC). The 0.05 reference scale marks a 5% estimated sequence variance. The figure was generated using MEGA644.