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. 2016 May 26;6:26628. doi: 10.1038/srep26628

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Copyright © 2016, Macmillan Publishers Limited

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Panel (A) Protein disorder prediction analysis of CYP144A1-FLV (red), CYP144A1-TRV (green) and the Mtb cholesterol hydroxylase CYP142A1 (blue). The threshold (black line) measure of the prediction’s false positive rate was set at 5%. The numbers of disordered amino acids in the protein sequence are indicated on the top panel. The figure was generated using PrDOS software³⁹. Panels (B,C) Multiangle Laser Light Scattering (MALLS) analysis of CYP144A1-TRV and CYP144A1-FLV, respectively. The refractive index (RI) data are shown as black lines in both cases, with the blue lines indicating the apparent molar mass of the relevant proteins. The data are consistent with both forms of CYP144A1 being monomeric in solution, and having molar masses of ~46,000 g/mol (CYP144A1-TRV) and ~49,000 g/mol (CYP144A1-FLV).