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. 2016 May 26;6:26657. doi: 10.1038/srep26657

Figure 1. Evx1 and Evx1as are co-expressed in the primitive streak during gastrulation.

Figure 1

(a) Schematic of the Evx1/Evx1as locus, and its proximity to the HoxA cluster modified from the UCSC genome browser. Wiggle track of Total RNAseq from E8 mouse Pre-Somatic Mesoderm (PSM) and Vertebrate Conservation tracks are also shown. Conservation of the Evx1as P1 region is boxed in red. (b) UCSC browser shot of the human EVX1 locus and the syntenic EVX1AS transcripts. (c) WISH of E7.5 and E9.5 mouse embryos using probes against Evx1 and Evx1as. Purple indicates the presence of the transcript. (d) Expression profiling of mESCs differentiated to day 4 EBs under serum-free conditions with the addition of BMP4 (10 ng/ml), WNT3A (20 ng/ml) or Activin A (10 ng/ml). Three replicates were performed for each condition. *Indicates p-value < 0.05, **indicates p-value < 0.01. All error bars indicate SEM.