Table 2. Changes in Brain MRI values (only significant changes on DTI are shown).

MR spectroscopic values	Cirrhosis without prior HE (n = 62)	Cirrhosis with prior HE (n = 85)
Parietal White Choline	0.28 ± 0.07	0.25 ± 0.05*
Parietal White Glx	2.12 ± 0.64	2.79 ± 0.81***
Parietal White mI	0.61 ± 0.36	0.31 ± 0.25***
Posterior Gray Choline	0.19 ± 0.03	0.18 ± 0.05
Posterior Gray Glx	2.29 ± 0.64	2.80 ± 0.73***
Posterior Gray mI	0.62 ± 0.27	0.39 ± 0.20***
Anterior Cingulate Choline	0.26 ± 0.04	0.23 ± 0.04*
Anterior Cingulate Glx	2.57 ± 0.64	3.23 ± 0.88***
Anterior Cingulate mI	0.61 ± 0.27	0.37 ± 0.22***
Diffusion tensor imaging (DTI)	Cirrhosis without prior HE (n = 31)	Cirrhosis with prior HE (n=42)
Spherical Isotropy
L Anterior Internal Capsule	0.48 ± 0.04	0.51 ± 0.02*
R Anterior Internal Capsule	0.47 ± 0.03	0.49 ± 0.03*
Corpus callosum genu	0.46 ± 0.05	0.48 ± 0.04*
Corpus callosum body	0.42 ± 0.05	0.45 ± 0.05*
Corpus callosum splenium	0.32 ± 0.04	0.34 ± 0.03*
R External Capsule	0.60 ± 0.03	0.62 ± 0.01*
L Frontal White	0.59 ± 0.03	0.61 ± 0.03*
R Posterior Internal Capsule	0.38 ± 0.2	0.40 ± 0.03*
R Superior Longitudinal Fasciculus	0.54 ± 0.03	0.58 ± 0.02*
Fractional Anisotropy
L Anterior Internal Capsule	0.58 ± 0.03	0.56 ± 0.02*
R Anterior Internal Capsule	0.60 ± 0.03	0.58 ± 0.03*
Corpus callosum genu	0.66 ± 0.03	0.64 ± 0.04*
Corpus callosum body	0.69 ± 0.04	0.66 ± 0.04*
Corpus callosum splenium	0.76 ± 0.02	0.74 ± 0.05*
R Cingulum	0.53 ± 0.03	0.50 ± 0.03*
L External Capsule	0.43 ± 0.03	0.41 ± 0.02*
R External Capsule	0.42 ± 0.03	0.31 ± 0.02*
L Frontal White	0.47 ± 0.03	0.44 ± 0.03*
R Frontal White	0.48 ± 0.03	0.46 ± 0.03*
L Posterior Internal Capsule	0.68 ± 0.02	0.66 ± 0.03*
R Posterior Internal Capsule	0.68 ± 0.02	0.66 ± 0.02*

*p < 0.05, ***p < 0.0001, All spectroscopic values are ratios of creatine, Glx: glutamate + glutamine, mI: myoinositol, R: right, L: left, HE: hepatic encephalopathy. No changes on mean diffusivity were seen between groups.