Table 3. Differences in human stool microbiota composition.
| % relative abundance | Controls (n = 40) | Cirrhosis without prior HE (n=62) | Cirrhosis with prior HE (n = 85) |
|---|---|---|---|
| Phylum (Mean ± SD) | |||
| Firmicutes | 50.5 ± 13.0 | 28.0 ± 19.0† | 24.0 ± 20.0* |
| Bacteroidetes | 33.0 ± 29.7 | 33.0 ± 30.0 | 24.0 ± 26.0* |
| Proteobacteria | 1.4 ± 3.0 | 3.0 ± 6.0† | 7.0 ± 15.0* |
| Phylum_Family (Mean ± SD) | |||
| Bacteroidetes_Bacteroidaceae | 21.0 ± 15.9 | 22.2 ± 24.0 | 18.2 ± 25.2* |
| Bacteroidetes_Porphyromonadaceae | 5.0 ± 8.7 | 2.1 ± 5.2 | 3.9 ± 7.7* |
| Bacteroidetes_Prevotellaceae | 4.7 ± 14.7 | 4.5 ± 13.5 | 2.9 ± 8.0* |
| Bacteroidetes_Rikenelleaceae | 2.2 ± 2.6 | 2.0 ± 5.5 | 0.0 ± 2.4* |
| Firmicutes_Lactobacillaceae | 0.0 ± 1.7 | 2.0 ± 8.5† | 4.0 ± 9.5* |
| Firmicutes_Enterococcaceae | 0.0 ± 0.0 | 1.1 ± 6.7† | 3.6 ± 10.9* |
| Firmicutes_Clostridiales XIV | 8.7 ± 5.9 | 3.2 ± 4.7† | 1.4 ± 3.5* |
| Firmicutes_Lachnospiraceae | 23.7 ± 7.9 | 10.5 ± 8.4† | 6.3 ± 11.0* |
| Firmicutes_Ruminococcaceae | 13.4 ± 6.9 | 5.5 ± 6.2 | 3.0 ± 5.4* |
| Firmicutes_Veillonellaceae | 2.2 ± 3.2 | 1.7 ± 2.9 | 2.0 ± 4.8 |
| Proteobacteria_Enterobacteriaceae | 0.0 ± 0.0 | 2.4. ± 5.9† | 5.5 ± 14.8* |
*p < 0.05 in HE subjects compared to controls and those without HE, †p < 0.05 in cirrhosis without HE compared to controls; HE: hepatic encephalopathy.