Fig. 7.

SP induces cleavage of CD163 in monocytes. sCD163 was measured by ELISA in the supernatant of freshly isolated human monocytes treated with SP and aprepitant as indicated. a Time course of cells treated with varying doses of SP as indicated. *p < 0.001 control versus 5 and 10 μM of SP. b Cells were pre-incubated with aprepitant (10 μM) for 30 min and then treated with SP (5 μM) for 60 min. *p < 0.001 SP versus control, p = 0.004 SP versus SP + aprepitant. Results are presented as mean ± SD from three independent experiments